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Caspase 8 monoclonal antibody

货号: MB67106

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB67106

Product Name :Caspase 8 monoclonal antibody

Swiss-Prot :Q14790

Host :Mouse

Reactivity :Human

Applications :WB, FC

Application_all :WB (1/500 - 1/1000), FC (1/10 - 1/50)

Background :Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10. Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.

Product :Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Caspase 8 protein.

BiowMW :~ 57 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis，Death Receptor Signaling，ErbB HER Signaling，Inhibition of Apoptosis，Mitochondrial Control of Apoptosis，Toll-like Receptor signaling

Alternative Name :MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Caspase 8. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Caspase 8 expression in HepG2 (A), Jurkat (B), HL60 (C) whole cell lysates.