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SCAP monoclonal antibody

货号: MB67084

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB67084

Product Name :SCAP monoclonal antibody

Swiss-Prot :Q12770

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/1000 - 1/2000)

Background :SREBP cleavage activating protein (SCAP) is a membrane-bound protein essential in regulating sterol regulatory element binding protein (SREBP) processing. In cholesterol-starved cells, SREBPs move from the ER to the Golgi apparatus with the help of SCAP, where the precursor SREBPs are cleaved by site-1 (S1P) and site-2 (S2P) proteases. Released SREBP amino-terminal domains enter the nucleus and bind to sterol response elements located in the promoters of a number of genes responsible for the cholesterol synthesis. Research studies show that the SCAP/SREBP pathway is critical for diabetic fatty liver development and carbohydrate-induced hypertriglyceridemia in mice. In addition, the SCAP/SREBP pathway is required to protect cancer cells from lipotoxicity.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of SCAP protein.

BiowMW :~ 115 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAA0199; Sterol regulatory element-binding protein cleavage-activating protein; SCAP; SREBP cleavage-activating protein

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human SCAP. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of SCAP expression in HT29 (A), LNCaP (B) whole cell lysates.

免疫沉淀（IP）