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Rbx1 monoclonal antibody

货号: MB67050

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB67050

Product Name :Rbx1 monoclonal antibody

Swiss-Prot :P62877

Host :Mouse

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :RING-box protein 1 (RBX1 or ROC1) is an essential component of two distinct but structurally related E3 ubiquitin ligase complexes, the SCF complex and the CBC (VHL) complex . RBX1 mediates the neddylation of CUL1, which activates SCF E3 ligase by facilitating the ubiquitin transfer from E2 to substrates . The RING finger domain of RBX1 is required for ubiquitin ligation . Two evolutionarily conserved mammalian RBX family members, RBX1/ROC1 and RBX2/ROC2/SAG, have been identified . RBX1 is constitutively expressed and binds to CUL2/VHL, while stress-inducible RBX2 binds to CUL5/SOCS .

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Rbx1 protein.

BiowMW :~ 13 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis.

Alternative Name :RNF75; ROC1; E3 ubiquitin-protein ligase RBX1; Protein ZYP; RING finger protein 75; RING-box protein 1; Rbx1; Regulator of cullins 1

Immunogen :Recombinant fusion protein of human Rbx1. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Rbx1 expression in Hela (A), NIH3T3 (B) whole cell lysates.