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Beta 2 Microglobulin monoclonal antibody

货号: MB67043

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB67043

Product Name :Beta 2 Microglobulin monoclonal antibody

Swiss-Prot :P61769

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :β2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system . As an integral component of the MHC class I complex, β2-microglobulin plays a critically important role in immune system function . It has important relevance to cancer biology research; for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that inactivate β2-microglobulin gene function, thereby allowing tumor cells to escape immune detection . In addition, β2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity ; its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy .

Product :Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Beta 2 Microglobulin protein.

BiowMW :~ 12 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Beta-2-microglobulin

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Beta 2 Microglobulin. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Beta 2 Microglobulin expression in Jurkat (A), Hela (B) whole cell lysates.