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RAB8A monoclonal antibody

货号: MB67039

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB67039

Product Name :RAB8A monoclonal antibody

Swiss-Prot :P61006

Host :Mouse

Reactivity :Human, Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :The Rab8 GTPase is a member of the Ras superfamily that functions in protein transport and membrane restructuring . Studies show that Rab8 is localized to the trans Golgi network (TGN), basolateral membrane, and vesicular structures where it helps regulate target protein transport between TGN and the basolateral membrane . Overexpression studies and mutation analysis of Rab8 and its associated Rab8GEF indicate additional roles in actin and microtubule remodeling during polarized membrane transport and membrane protrusion formation . Rab8 associates with myosin Vb and is required for translocation of GLUT4 following insulin stimulation in muscle . Control of target protein vesicle transport by Rab8 also regulates MT1-MMP activity during extracellular matrix formation and JRAB/MICAL-L2 at tight junction formation .

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of RAB8A protein.

BiowMW :~ 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MEL; RAB8; Ras-related protein Rab-8A; Oncogene c-mel

Immunogen :Recombinant fusion protein of human RAB8A. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of RAB8A expression in Hela (A), HCT116 (B) whole cell lysates.

免疫沉淀（IP）