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NALP12 monoclonal antibody

货号: MB67033

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB67033

Product Name :NALP12 monoclonal antibody

Swiss-Prot :E9Q5R7

Host :Mouse

Reactivity :Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Plays an essential role as an potent mitigator of inflammation.Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways .Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway .In turn, promotes bacterial tolerance.Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (By similarity).Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue .

Product :Mouse IgM kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of NALP12 protein.

BiowMW :~ 119 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NALP12; PYPAF7; RNO; NACHT, LRR and PYD domains-containing protein 12; Monarch-1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide

Immunogen :Recombinant fusion protein of human NALP12. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of NALP12 expression in mouse brain (A) whole cell lysates.