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NR2C2 monoclonal antibody

货号: MB66995

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB66995

Product Name :NR2C2 monoclonal antibody

Swiss-Prot :P49116

Host :Mouse

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Testicular receptor 4 (TR4), also called TAK1 or NR2C2, is an orphan receptor in a distinct subclass of the steroid hormone nuclear receptor superfamily along with TR2 . TR4 forms heterodimers with TR2 and binds to DNA elements containing direct repeats (DRs) . TR4 plays a role in various processes, including neurogenesis, spermatogenesis, RNA metabolism, and protein translation . TR4 can interact with other hormone receptors such as AR and ER to influence protein-protein binding and target gene inactivation . High expression of TR4 correlates with prostate cancer metastasis and invasion through downstream targets such as CCL2 and Ezh2 . Expression of TR4 in other cancers such as NSCLC and testicular germ cell tumors has also been associated with poor prognosis .

Product :Mouse IgG2b kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of NR2C2 protein.

BiowMW :~ 67 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TAK1; TR4; Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4

Immunogen :KLH-conjugated synthetic peptide of human NR2C2. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of NR2C2 expression in PC3 (A), Jurkat (B), MoLT4 (C), F9 (D), NIH3T3 (E), PC12 (F), CHO (G) whole cell lysates.