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SOX9 monoclonal antibody

货号: MB66994

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB66994

Product Name :SOX9 monoclonal antibody

Swiss-Prot :P48436

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/1000 - 1/5000)

Background :Sox9 is a transcription factor with an HMG-box DNA binding domain that has homology to the HMG domain of the mammalian testis-determining factor, SRY . Sox9 regulates several important processes during embryonic development including chondrogenesis, during which it contributes to skeletal formation and digit specification . Sox9 also coordinates with steroidogenic factor-1 to direct Sertoli cell-specific expression of anti-Mullerian hormone during embryogenesis, thereby contributing to male sex determination . In addition, Sox9 is reportedly involved in the maintenance of adult stem cell populations, including multipotent neural stem cells , hair follicle stem cells , and mammary stem cells . Recent interest has focused on the role of Sox9 in tumor biology. For example, research studies have shown that Sox9 expression in lung adenocarcinoma induces a mesenchymal phenotype in tumor cells . Other research studies have shown that YAP1 induced upregulation of Sox9 confers cancer stem cell like properties on esophageal cancer cells . Moreover, Sox9 expression has been linked with several other tumor types including ovarian, prostate, and pancreatic malignancies .

Product :Mouse IgM. Supplied in crude ascites with 0.01% sodium azide.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of SOX9 protein.

BiowMW :~ 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Transcription factor SOX-9

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human SOX9. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of SOX9 expression in HepG2 (A) whole cell lysates.

免疫沉淀（IP）

免疫组织化学（IHC）