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STAT1 monoclonal antibody

货号: MB66983

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66983

Product Name :STAT1 monoclonal antibody

Swiss-Prot :P42224

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :The Stat1 transcription factor is activated in response to a large number of ligands and is essential for responsiveness to IFN-α and IFN-γ . Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding . Stat1 protein exists as a pair of isoforms, Stat1α (91 kDa) and the splice variant Stat1β (84 kDa). In most cells, both isoforms are activated by IFN-α, but only Stat1α is activated by IFN-γ. The inappropriate activation of Stat1 occurs in many tumors . In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK)-dependent pathway in response to IFN-α and other cellular stresses . Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation.

Product :Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of STAT1 protein.

BiowMW :~ 83 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :ErbB HER Signaling,MAPK Erk in Growth and Differentiation Pathway,Jak Stat ：IL-6 Receptor Signaling,Inhibition of Apoptosis,Signaling Pathways Activating p38 MAP Kinase.

Alternative Name :Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84

Immunogen :Recombinant fusion protein of human STAT1. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of STAT1 expression in CEM (A), Hela (B) whole cell lysates.