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AREB6 monoclonal antibody

货号: MB66977

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66977

Product Name :AREB6 monoclonal antibody

Swiss-Prot :P37275

Host :Mouse

Reactivity :Human

Applications :WB, FC

Application_all :WB (1/500 - 1/5000), FC (1/10 - 1/50)

Background :ZEB family proteins are zinc-finger and homeobox domain containing transcription factors. There are two members in mammals, ZEB1 (δ-EF1, TCF8, AREB6) and ZEB2 (SIP1). ZEB1 and ZEB2 contain two separate zinc-finger domains and a homeodomain (1). While ZEB proteins mainly function as transcriptional suppressors, they are able to activate transcription, dependent on DNA-context and cell type . One of the targets suppressed by ZEB proteins is E-cadherin. Downregulation of E-cadherin is one of the hallmarks of epithelial mesenchymal transition (EMT), a critical feature of normal embryonic development, which is also utilized by malignant epithelial tumors to spread beyond their origin . ZEB1 mutations are associated with posterior corneal dystrophy, and ZEB2 mutations were reported to be associated with Hirschsprung (HSCR) disease .

Product :Mouse IgG1 kappa. Supplied in crude ascites with 0.01% sodium azide.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of AREB6 protein.

BiowMW :~ 95 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Adherens Junction signaling,Wntβ catenin signaling.

Alternative Name :AREB6; TCF8; Zinc finger E-box-binding homeobox 1; NIL-2-A zinc finger protein; Negative regulator of IL2; Transcription factor 8; TCF-8

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AREB6. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of AREB6 expression in A549 (A) whole cell lysates.