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Beta-catenin monoclonal antibody

货号: MB66970

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66970

Product Name :Beta-catenin monoclonal antibody

Swiss-Prot :P35222

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB, IF/ICC

Application_all :WB (1/1000 - 1/2000), IF/ICC (1/10 - 1/50)

Background :β-catenin is a key downstream effector in the Wnt signaling pathway . It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis . CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β . GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41 . Mutations at these sites result in the stabilization of β-catenin protein levels and have been found in many tumor cell lines .

Product :Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Beta-catenin protein.

BiowMW :~ 92 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Adherens Junction signaling,ESC Pluripotency and Differentiation Signaling Pathway,ErbB HER Signaling,Wntβ catenin signaling.

Alternative Name :CTNNB; Catenin beta-1; Beta-catenin

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Beta-catenin. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Beta-catenin expression in 293 (A), Hela (B), COS7 (C), C6 (D), NIH3T3 (E) whole cell lysates.