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FGFR4 monoclonal antibody

货号: MB66933

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB66933

Product Name :FGFR4 monoclonal antibody

Swiss-Prot :P22455

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/1000 - 1/2000)

Background :Fibroblast growth factors produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1, FGFR2 , FGFR3, and FGFR4. Each receptor contains an extracellular ligand-binding domain, a transmembrane domain, and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling . The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components, such as Crk and PLC纬 .

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of FGFR4 protein.

BiowMW :~ 88 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,ESC Pluripotency and Differentiation Signaling Pathway,

Alternative Name :JTK2; TKF; Fibroblast growth factor receptor 4; FGFR-4; CD334

Immunogen :Recombinant fusion protein of human FGFR4. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of FGFR4 expression in FGFR4 recombinant protein (A) whole cell lysates.