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HNF1 alpha monoclonal antibody

货号: MB66924

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66924

Product Name :HNF1 alpha monoclonal antibody

Swiss-Prot :P20823

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Hepatocyte nuclear factor 1伪 is a transcription factor that plays a role in the tissue-specific regulation of liver gene expression. Research has shown that heterogeneous mutations of HNF1伪 are linked to maturity onset diabetes of the young . Recent studies indicate that increased concentrations of free fatty acids can reduce the expression of FoxA2/HNF3尾 and HNF1伪 in pancreatic 尾-cells and lead to their nuclear exclusion, resulting in symptoms of several metabolic syndromes .

Product :Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of HNF1 alpha protein.

BiowMW :~ 81 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Adherens Junction signaling,Wntβ catenin signaling

Alternative Name :TCF1; Hepatocyte nuclear factor 1-alpha; HNF-1-alpha; HNF-1A; Liver-specific transcription factor LF-B1; LFB1; Transcription factor 1; TCF-1

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HNF1 alpha. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of HNF1 alpha expression in NCIH460 (A) whole cell lysates.