Product Name :c-SRC monoclonal antibody
Application_all :WB (1/500 - 1/1000), IF/ICC (1/10 - 1/50)
Background :The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells . Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active .
Product :Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Purification&Purity :This antibody is purified through a protein G column.
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of c-SRC protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Regulation of Actin Dynamics,Adherens Junction signaling,Tumor Angiogenesis,ErbB HER Signaling,G Protein-coupled Receptors Signaling to MAPK Erk,Jak Stat ：IL-6 Receptor Signaling,Inhibition of Apoptosis,Regulation of Microtubule Dynamics,Signaling Pathways Activating p38 MAP Kinase,Wntβ catenin signaling
Alternative Name :SRC1; Proto-oncogene tyrosine-protein kinase Src; Proto-oncogene c-Src; pp60c-src; p60-Src
Immunogen :Recombinant fusion protein of human c-SRC. The exact sequence is proprietary.
Modification :Unmodification
