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GRP78 monoclonal antibody

货号: MB66860

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB66860

Product Name :GRP78 monoclonal antibody

Swiss-Prot :P11021

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/1000 - 1/5000)

Background :Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum . Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including BiP. BiP was identified as an immunoglobulin heavy chain binding protein in pre-B cells . It was also found to be induced at the protein level by glucose starvation . When protein folding is disturbed inside ER, BiP synthesis is increased. Subsequently, BiP binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding .

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of GRP78 protein.

BiowMW :~ 78 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP

Immunogen :Recombinant fusion protein of human GRP78. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of GRP78 expression in HepG2 (A), MCF7 (B), Jurkat (C), mouse liver (D), rat liver (E) whole cell lysates.