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CD115 monoclonal antibody

货号: MB66823

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66823

Product Name :CD115 monoclonal antibody

Swiss-Prot :P07333

Host :Mouse

Reactivity :Human

Applications :WB, IHC, FC

Application_all :WB (1/500 - 1/2000), IHC (1/50 - 1/200), FC (1/10 - 1/50)

Background :c-Fms/CSF-1R, also designated macrophage colony-stimulating factor receptor (M-CSFR), FIM2 or CD115, is a transmembrane tyrosine kinase receptor belonging to the CSF1/PDGF receptor family. It is encoded by the c-Fms protooncogene and is expressed in mononuclear phagocytes, oocytes, decidual cells, trophoblastic cells and some myoblasts. It is important for growth and differentiation of myeloid cells and its function can be regulated by SLAP-2. c-Fms/CSF-1R is responsible for mediating all of the functions of M-CSF. M-CSF is a glycoprotein required for the proliferation and differentiation of mononuclear phagocytes, including osteoclasts. M-CSF has also been identified as an important mediator of the inflammatory response and can regulate the release of proinflammatory cytokines from macrophages.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of CD115 protein.

BiowMW :~ 105 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :FMS; Macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD115

Immunogen :Recombinant fusion protein of human CD115. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of CD115 expression in U87MG (A) whole cell lysates.

Immunohistochemical analysis of CD115 staining in human skin formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.