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EIF4E monoclonal antibody

货号: MB66816

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66816

Product Name :EIF4E monoclonal antibody

Swiss-Prot :P06730

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB, IF/ICC

Application_all :WB (1/1000 - 1/2000), IF/ICC (1/10 - 1/50)

Background :The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors and RNA molecules. The eukaryotic initiation complex eIF4F exists in vitro as a trimeric complex of eIF4E, eIF4A and eIF4G. Together, the complex allows ribosome binding to mRNA by inducing the unwinding of mRNA secondary structures. eIF4E binds to the mRNA “cap” during an early step in the initiation of protein synthesis. eIF4A acts as an ATP-dependent RNA helicase. eIF4G acts as a bridge between eIF4E, eIF4A and the eIF3 complex.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of EIF4E protein.

BiowMW :~ 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Translational Contral elF4 and p70 S6 Kinase

Alternative Name :EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein

Immunogen :Recombinant fusion protein of human EIF4E. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of EIF4E expression in Hela (A), MCF7 (B), K562 (C), NIH3T3 (D), PC12 (E) whole cell lysates.