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CD31 monoclonal antibody

货号: MB66677

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB66677

Product Name :CD31 monoclonal antibody

Swiss-Prot :P16284

Host :Mouse

Reactivity :Human

Applications :WB IHC IF/ICC

Application_all :WB: 1:500~1:1000 IHC: 1:100~1:300 IF/ICC: 1:100~1:300

Background :CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules.

Product :Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD31 monoclonal antibody detects endogenous levels of CD31 protein.

BiowMW :~ 130 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; CD31

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within human CD31.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of CD31 expression in MDAMB231 (A), Hela (B) whole cell lysates.

Immunohistochemical analysis of CD31 staining in human hemangioendothelioma formalin fixed paraffin embedded tissue section.

Immunofluorescent analysis of CD31 staining in HUVEC cells.

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