Product Name :Progesterone Receptor monoclonal antibody
Application_all :IHC (1/100 - 1/300)
Background :Human progesterone receptor (PR) is expressed as two forms: the full length PR-B and the short form PR-A. PR-A lacks the first 164 amino acid residues of PR-B (1,2). Both PR-A and PR-B are ligand activated, but differ in their relative ability to activate target gene transcription (3,4). The activity of PR is regulated by phosphorylation; at least seven serine residues are phosphorylated in its amino-terminal domain. Three sites (Ser81, Ser102, and Ser162) are unique to full length PR-B, while other sites (Ser190, Ser294, Ser345, and Ser400) are shared by both isoforms . Phosphorylation of PR-B at Ser190 (equivalent to Ser26 of PR-A) is catalyzed by CDK2 . Mutation of Ser190 results in decreased activity of PR , suggesting that the phosphorylation at Ser190 may be critical to its biological function.
Product :Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.
Purification&Purity :The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Recognizes endogenous levels of Progesterone Receptor protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :NR3C3; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within human Progesterone Receptor. The exact sequence is proprietary.
Modification :Unmodification
