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MAPK9 (JNK2) mouse monoclonal antibody (KU)

货号: MB4366

价格：￥ 398

货期：现货（1-2个工作日）

25ul 50ul 100ul

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No. :MB4366

Product Name :MAPK9 (JNK2) mouse monoclonal antibody (KU)

Swiss-Prot :P45984

Host :Mouse

Reactivity :Human, Dog, Rat, Monkey, Mouse

Applications :IF, IHC, WB

Application_all :WB 1:200, IHC 1:150, IF 1:100

Background :The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG1

BiowMW :~ 53 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :E3 ubiquitin-protein ligase TRIM38; EC:2.3.2.27; RING finger protein 15; Tripartite motif-containing protein 38 ; Zinc finger protein RoRet; TRIM38

Immunogen :Human recombinant protein fragment corresponding to amino acids 1-265 of human TRIM38(NP_006346) produced in E.coli.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TRIM38 mouse monoclonal antibody at 1:500 dilution. Lane1:HepG2 whole cell lysate(30ug)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TRIM38 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min)

Anti-TRIM38 mouse monoclonal antibodyimmunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TRIM38 (RC201944).