产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

MAP2K2 (MEK2 ) mouse monoclonal antibody (KU)

货号: MB4363

价格：￥ 398

货期：现货（1-2个工作日）

25ul 50ul 100ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB4363

Product Name :MAP2K2 (MEK2 ) mouse monoclonal antibody (KU)

Swiss-Prot :P36507

Host :Mouse

Reactivity :Human, Dog, Rat, Monkey, Mouse

Applications :IF, IHC, WB

Application_all :WB 1:200, IHC 1:150, IF 1:100

Background :The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG1

BiowMW :~ 53 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :E3 ubiquitin-protein ligase TRIM38; EC:2.3.2.27; RING finger protein 15; Tripartite motif-containing protein 38 ; Zinc finger protein RoRet; TRIM38

Immunogen :Human recombinant protein fragment corresponding to amino acids 1-265 of human TRIM38(NP_006346) produced in E.coli.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TRIM38 mouse monoclonal antibody at 1:500 dilution. Lane1:HepG2 whole cell lysate(30ug)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TRIM38 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min)

Anti-TRIM38 mouse monoclonal antibodyimmunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TRIM38 (RC201944).