Product Name :PDIA4 (ERp72) mouse monoclonal antibody (KU)
Reactivity :Human, Dog, Monkey, Mouse, Rat
Application_all :WB 1:500~2000, IHC 1:150
Background :Mammals defend themselves against intracellular pathogens through presentation of cytoplasmically derived short pathogenic peptides to the cellsurface of cytotoxic T lymphocytes, which subsequently leads to cytotoxicevents with respect to the affected cell. Antigen presentation is mediated bymajor histocompatibility complex (MHC) class I molecules, which bind andcoordinate short pathogenic peptides. The proper folding and assembly ofMHC class I molecules in the endoplasmic reticulum (ER) involve a numberof components. MHC class I molecules assemble in the ER with chaperonesbefore binding to the transporter associated with antigen processing (TAP)protein. ERp57 is a component of the MHC class I pathway that appears tointeract with MHC class I molecules before they associate with TAP. ERp72,also designated protein disulfide-isomerase A4, is involved in the catalysisof protein-S-S-bond rearrangement. ERp57 and ERp72 may act as proteases,protein disulfide isomerases, phospholipases or a combination of these.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :ERp-72; ERP70; ERP72
Immunogen :Full length human recombinant protein of human PDIA4(NP_004902) produced in HEK293T cell.
Modification :Unmodification
