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ERBB2 mouse monoclonal antibody (KU)

货号: MB4316

价格：￥ 398

货期：现货（1-2个工作日）

25ul 50ul 100ul

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No. :MB4316

Product Name :ERBB2 mouse monoclonal antibody (KU)

Swiss-Prot :P04626

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :FC, IF, IHC, WB

Application_all :WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100

Background :This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG2b

BiowMW :~ 50 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Tubulin alpha chain-like 3; TUBAL3

Immunogen :Human recombinant protein fragment corresponding to amino acids 150-446 of human TUBAL3(NP_079079) produced in E.coli.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TUBAL3 mouse monoclonal antibody at 1:500 dilution Lane1:HepG2 whole cell lysate(30ug)

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-TUBAL3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100°C for 10min)

Anti-TUBAL3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TUBAL3.