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Notch1 mouse monoclonal antibody (KU)

货号: MB4127

价格：￥ 398

货期：现货（1-2个工作日）

25ul 50ul 100ul

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No. :MB4127

Product Name :Notch1 mouse monoclonal antibody (KU)

Swiss-Prot :P46531

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :IF, IHC, WB

Application_all :WB 1:200, IHC 1:150, IF 1:100

Background :Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG1

BiowMW :~ 53 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :E3 ubiquitin-protein ligase TRIM38; EC:2.3.2.27; RING finger protein 15; Tripartite motif-containing protein 38 ; Zinc finger protein RoRet; TRIM38

Immunogen :Human recombinant protein fragment corresponding to amino acids 1-265 of human TRIM38(NP_006346) produced in E.coli.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TRIM38 mouse monoclonal antibody at 1:500 dilution. Lane1:HepG2 whole cell lysate(30ug)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TRIM38 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min)

Anti-TRIM38 mouse monoclonal antibodyimmunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TRIM38 (RC201944).