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SNAI2 (SLUG) mouse monoclonal antibody (KU)

货号: MB4050

价格：￥ 398

货期：现货（1-2个工作日）

25ul 50ul 100ul

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No. :MB4050

Product Name :SNAI2 (SLUG) mouse monoclonal antibody (KU)

Swiss-Prot :O43623

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :IF, WB

Application_all :WB 1:2500~5000, IF 1:50~100

Background :Slug (SNAI2) is a widely expressed transcriptional repressor and member of the Snail family of zinc finger transcription factors. Similar to the related Snail protein, Slug binds to the E-cadherin promoter region to repress transcription during development. The binding of Slug to integrin promoter sequences represses integrin expression and results in reduced cell adhesion. Down regulation of E-cadherin expression occurs during the epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells. The tumor suppressor protein p53 induces Slug expression in γ-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Deletion mutations in the corresponding Slug gene are associated with the pigmentation disorders Waardenburg Syndrome and Piebaldism, while a genetic duplication resulting in Slug overexpression is associated with a collection of congenital heart defects termed tetralogy of Fallot.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites fluids or tissue culture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG1

BiowMW :~ 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit (DFF-45); Inhibitor of CAD (ICAD)

Immunogen :Full length human recombinant protein of human DFFA (NP_004392) produced in E.coli.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of DFF45 (ICAD) mouse monoclonal antibody at 1:500 dilution. Lane1:A549 whole cell lysate(30ug)

免疫沉淀（IP）

免疫组织化学（IHC）

免疫荧光（IF）