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CD45 monoclonal antibody

货号: MB3159

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB3159

Product Name :CD45 monoclonal antibody

Swiss-Prot :P08575

Host :Mouse

Reactivity :Human,Mouse

Applications :WB,IHC-P

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100

Background :The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG1

BiowMW :Calculated MW: 147 kDa; Observed MW: 180-240kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PTPRC; CD45; Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen; L-CA; T200; CD antigen CD45

Immunogen :Purified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodified

Immunohistochemistry analysis of paraffin-embedded breast cancer tissues using PTPRC antibody with DAB staining.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.

Immunohistochemistry analysis of paraffin-embedded esophageal cancer tissues using PTPRC antibody with DAB staining.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.