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Toll-Like Receptor 3 (2F10) monoclonal antibody

货号: MB3091

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB3091

Product Name :Toll-Like Receptor 3 (2F10) monoclonal antibody

Swiss-Prot :O15455

Host :Mouse

Reactivity :Transfected

Applications :WB

Application_all :WB: 1/500-1/1000

Background :The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG2b

BiowMW :Calculated MW: 104 kDa; Observed MW: Refer to figures

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CD283; CD283 antigen; IIAE2; TLR 3; Tlr3; TLR3_HUMAN; Toll Like Receptor 3; Toll-like receptor 3.

Immunogen :Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Toll-Like Receptor 7 in CHO-K1 lysatesand CHO-K1 transfected by Toll-Like Receptor 3 lysates using Toll-Like Receptor 3 antibody.