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Cyclin D2 (6E11) monoclonal antibody

货号: MB3016

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB3016

Product Name :Cyclin D2 (6E11) monoclonal antibody

Swiss-Prot :P30279

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB: 1/500-1/1000

Background :The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and Ticular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3).

Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG2b

BiowMW :Calculated MW: 33 kDa; Observed MW: 38 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :KIAK0002.

Immunogen :Purified recombinant human Cyclin D2 protein fragments expressed in E.coli.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Cyclin D2 in CHO-K1 lysates and CHO-K1 transfected by Cyclin D2fragment EGFP fusion proteinlysates using Cyclin D2 antibody.

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