Product Name :HP1 alpha monoclonal antibody
Reactivity :Human,Mouse,Rat
Applications :WB,ICC/IF,IHC-F,IHC-P
Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Background :Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Product :Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification&Purity :Affinity Purified
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BiowMW :Calculated MW: 22 kDa; Observed MW: 26 kDa
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
Immunogen :Purified recombinant human HP1 alpha protein fragments expressed in E.coli.
