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NEDD8 Activating Enzyme E1C monoclonal antibody

货号: MB12290

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB12290

Product Name :NEDD8 Activating Enzyme E1C monoclonal antibody

Swiss-Prot :Q8TBC4

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB

Application_all :WB: 1/500-1/1000

Background :The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 52 kDa; Observed MW: 52 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :NAE2; UBE1C; hUBA3

Immunogen :A synthetic peptide of human UBA3

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of UBA3 in Raw264.7 lysates using NEDD8 Activating Enzyme E1C antibody.

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