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RASA1 monoclonal antibody

货号: MB12225

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB12225

Product Name :RASA1 monoclonal antibody

Swiss-Prot :P20936

Host :Rabbit

Reactivity :Human

Applications :WB,IHC-P

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100

Background :The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 116 kDa; Observed MW: 140 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GAP; PKWS; RASA; p120; CMAVM; CM-AVM; CMAVM1; RASGAP; p120GAP; p120RASGAP

Immunogen :A synthetic peptide of human RASA1

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of RASA1 in A549, HL-60, U87-MG lysates using RASA1 antibody.

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using RASA1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.