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HMG4 monoclonal antibody

货号: MB12067

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB12067

Product Name :HMG4 monoclonal antibody

Swiss-Prot :O15347

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-P,IP

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background :Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters . Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor . Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling .

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 23 kDa; Observed MW: 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :HMG4; HMG-4; HMG2A; HMG-2a

Immunogen :A synthetic peptide of human HMG4

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of HMG4 in 3T3 lysates using HMG4 antibody.

Western blot analysis of HMG4 in Hela, A549, HL-60, U2OS, C6 lysates using HMG4 antibody.