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Phospho-Rb (Thr356) monoclonal antibody

货号: MB11892

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB11892

Product Name :Phospho-Rb (Thr356) monoclonal antibody

Swiss-Prot :P06400

Host :Rabbit

Reactivity :Human,Rat

Applications :WB,IHC-P,IP

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background :Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 106 kDa; Observed MW: 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Thr356 of human Rb

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Rb in HL-60, U2OS, C6 lysates using Phospho-Rb antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using Rb antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.