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Phospho-IRE1 (Ser724) monoclonal antibody

货号: MB11870

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB11870

Product Name :Phospho-IRE1 (Ser724) monoclonal antibody

Swiss-Prot :O75460

Host :Rabbit

Reactivity :Human

Applications :WB,IP

Application_all :WB: 1/500-1/1000 IP: 1/20

Background :Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 110 kDa; Observed MW: 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ERN1; IRE1; Serine/threonine-protein kinase/endoribonuclease IRE1; Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a

Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser724 of human IRE1

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-IRE1 in MCF-7, HL-60 lysates using Phospho-IRE1 antibody.