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Phospho-beta Arrestin 1 (Ser412) monoclonal antibody

货号: MB11849

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB11849

Product Name :Phospho-beta Arrestin 1 (Ser412) monoclonal antibody

Swiss-Prot :P49407

Host :Rabbit

Reactivity :Human

Applications :WB,IHC-P,IP

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background :Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 47 kDa; Observed MW: 50 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ARB1; ARR1; ARRB1; ARRB1_HUMAN; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1.

Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser412 of human beta Arrestin 1

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Phospho-beta Arrestin 1 in A549, MCF-7, U251, HL-60 lysates using Phospho-beta Arrestin 1 antibody.

Immunohistochemistry analysis of paraffin-embedded Human lung cancer using beta Arrestin 1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.