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PIM1 monoclonal antibody

货号: MB11820

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB11820

Product Name :PIM1 monoclonal antibody

Swiss-Prot :P11309

Host :Rabbit

Reactivity :Human

Applications :WB,IHC-P

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100

Background :Pim1 a proto-oncogene serine/threonine kinase involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerced by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 36 kDa; Observed MW: 36 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PIM1; Serine/threonine-protein kinase pim-1

Immunogen :A synthetic peptide of human PIM1

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of PIM1 in Hela, A549, HL-60 lysates using PIM1 antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using PIM1 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.