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TRIM24 monoclonal antibody

货号: MB11722

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

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No. :MB11722

Product Name :TRIM24 monoclonal antibody

Swiss-Prot :O15164

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1/500-1/1000

Background :Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes .

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 117 kDa; Observed MW: 117 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA

Immunogen :A synthetic peptide of human TRIM24

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of TRIM24 in K562, Hela lysates using TRIM24 antibody.

免疫沉淀（IP）