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STK3 monoclonal antibody

货号: MB11644

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB11644

Product Name :STK3 monoclonal antibody

Swiss-Prot :Q13188

Host :Rabbit

Reactivity :Human,Mouse,Rat,Hamster

Applications :WB,IHC-P,IP

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background :Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 56 kDa; Observed MW: 56 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :STK3; Mess1; MST-2; MST2; Serine/threonine kinase 3; KRS1; STE20-like kinase MST2

Immunogen :A synthetic peptide of human STK3

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of STK3/MST2 in 3T3, Raw264.7 lysates using STK3 antibody.

Western blot analysis of STK3/MST2 in CHO-K1, C6, Jurkat lysates using STK3/MST2 antibody.