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Securin monoclonal antibody

货号: MB11577

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB11577

Product Name :Securin monoclonal antibody

Swiss-Prot :O95997

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB,IHC-P,IP

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background :Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 22 kDa; Observed MW: 25 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :PTTG1; EAP1; PTTG; TUTR1; Securin; Esp1-associated protein; Pituitary tumor-transforming gene 1 protein; Tumor-transforming protein 1; hPTTG

Immunogen :A synthetic peptide of human Securin

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Securin in K562, 3T3, Hela lysates using Securin antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using Securin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.