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SC35 monoclonal antibody

货号: MB11567

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB11567

Product Name :SC35 monoclonal antibody

Swiss-Prot :Q01130

Host :Rabbit

Reactivity :Human,Rat

Applications :WB,IHC-P,IP

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/20

Background :Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 25 kDa; Observed MW: 35 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Protein PR264; Splicing component; 35 kDa; Splicing factor SC35; SC-35; Splicing factor; arginine/serine-rich 2

Immunogen :A synthetic peptide of human SC35

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of SC35 in C6, MCF-7 lysates using SC35 antibody.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using SC35 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.