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Phospho-Rb2 p130 (Ser952) monoclonal antibody

货号: MB11522

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB11522

Product Name :Phospho-Rb2 p130 (Ser952) monoclonal antibody

Swiss-Prot :Q08999

Host :Rabbit

Reactivity :Human

Applications :WB,IHC-F,IHC-P,ICC/IF

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200

Background :Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 128 kDa; Observed MW: 128 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Rb2; P130

Immunogen :A synthetic phosphopeptide corresponding to residues surrounding Ser952 of human Rb2 p130

Conjugate :Unconjugated

Modification :Phosphorylated

Western blot analysis of Rb2 p130 in K562, Hela lysates using Phospho-Rb2 p130 antibody.

Immunocytochemistry analysis of Rb2 p130 in Hela using Rb2 p130 antibody,and DAPI