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Pellino 1 monoclonal antibody

货号: MB11393

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB11393

Product Name :Pellino 1 monoclonal antibody

Swiss-Prot :Q96FA3

Host :Rabbit

Reactivity :Human,Rat

Applications :WB,IP

Application_all :WB: 1/500-1/1000 IP: 1/20

Background :E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609).

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 46 kDa; Observed MW: 46 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Pellino-related intracellular-signaling molecule; RING-type E3 ubiquitin transferase pellino homolog 1

Immunogen :Recombinant protein of human Pellino 1

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Pellino 1 in rat Brain, Jurkat lysates using Pellino 1 antibody.

免疫沉淀（IP）