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Lamin A/C monoclonal antibody

货号: MB11154

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB11154

Product Name :Lamin A/C monoclonal antibody

Swiss-Prot :P02545

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-F,IHC-P,ICC/IF,IP

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20

Background :Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 74 kDa; Observed MW: 74,63 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :LMNA; LMN1; Prelamin-A/C

Immunogen :A synthetic peptide of human Lamin A/C

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Lamin A/C in rat heart, rat skeletal muscle lysates using Lamin A/C antibody.

Western blot analysis of Lamin A/C in 3T3, Hela lysates using Lamin A/C antibody.