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Homer1 monoclonal antibody

货号: MB11053

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

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No. :MB11053

Product Name :Homer1 monoclonal antibody

Swiss-Prot :Q86YM7

Host :Rabbit

Reactivity :Mouse,Rat

Applications :WB,IP

Application_all :WB: 1/500-1/1000 IP: 1/20

Background :Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines .

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 40 kDa; Observed MW: 46 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C

Immunogen :Recombinant protein of human Homer1

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Homer1 in mouse brain lysates using Homer1 antibody.

免疫沉淀（IP）