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Glucocorticoid Receptor monoclonal antibody

货号: MB10977

价格：￥ 1350

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB10977

Product Name :Glucocorticoid Receptor monoclonal antibody

Swiss-Prot :P06537

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,ICC/IF

Application_all :WB: 1/500-1/1000 IF: 1/50-1/200

Background :Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 87 kDa; Observed MW: 94,91 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :GR; GCR; GRL; GCCR; GCRST

Immunogen :Recombinant protein of mouse Glucocorticoid Receptor

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Glucocorticoid Receptor in rat skeletal muscle lysates using Glucocorticoid Receptor antibody.

免疫沉淀（IP）