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GNA13 monoclonal antibody

货号: MB10948

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB10948

Product Name :GNA13 monoclonal antibody

Swiss-Prot :Q14344

Host :Rabbit

Reactivity :Human

Applications :WB,IHC-P

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100

Background :Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) . Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 44 kDa; Observed MW: 44 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :guanine nucleotide binding protein (G protein); alpha 13; G13

Immunogen :A synthetic peptide of human G protein alpha 13

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of GNA13 [KO Validated] in Hela, Jurkat lysates using GNA13 antibody.

Immunohistochemistry analysis of paraffin-embedded Human Cholangiocarcinoma using G protein alpha 13 antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.