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XPO4 monoclonal antibody

货号: MB10896

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB10896

Product Name :XPO4 monoclonal antibody

Swiss-Prot :Q9C0E2

Host :Rabbit

Reactivity :Human,Rat

Applications :WB,IP

Application_all :WB: 1/500-1/1000 IP: 1/20

Background :Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 130 kDa; Observed MW: 130 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :exp4

Immunogen :A synthetic peptide of human Exportin 4

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Exportin 4 in MCF-7, C6 lysates using XPO4 antibody.

免疫沉淀（IP）