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DOCK8 monoclonal antibody

货号: MB10844

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :MB10844

Product Name :DOCK8 monoclonal antibody

Swiss-Prot :Q8NF50

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1/500-1/1000

Background :Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151, PubMed:22461490). During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC . Required for CD4+ T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 239 kDa; Observed MW: 239 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :MRD2; ZIR8; HEL-205

Immunogen :Recombinant protein of human DOCK8

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of DOCK8 in Ramos lysates using DOCK8 antibody.

免疫沉淀（IP）