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Cullin 5 monoclonal antibody

货号: MB10782

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB10782

Product Name :Cullin 5 monoclonal antibody

Swiss-Prot :Q93034

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1/500-1/1000

Background :Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 91 kDa; Observed MW: 91 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CUL-5; VACM1; VACM-1

Immunogen :Recombinant protein of human Cullin 5

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of Cullin 5/CUL5 in C6, 3T3, Hela lysates using Cullin 5 antibody.

免疫沉淀（IP）