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CPSF6 monoclonal antibody

货号: MB10761

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB10761

Product Name :CPSF6 monoclonal antibody

Swiss-Prot :Q16630

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC-F,IHC-P,ICC/IF,IP

Application_all :WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200 IP: 1/20

Background :Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460).

Product :50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification&Purity :Affinity Purified

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IgG

BiowMW :Calculated MW: 59 kDa; Observed MW: 70 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CFIM; CFIM68; CFIM72; HPBRII-4; HPBRII-7

Immunogen :A synthetic peptide of human CPSF6

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of CPSF6 in rat Brain, MCF-7, 3T3, C6 lysates using CPSF6 antibody.

免疫沉淀（IP）